Predictors of neuro-cognitive decline and survival in HIV-infected subjects (A collaboration between SEARCH, Phramongkutklao Hospital, University of Hawaii and AFRIMS)

Colonel Dr. Samart Nidhinandana: Principal Investigator, Dr. Victor Valcour: co-Principal Investigator and Rank Captain Dr. Pasiri Sithinamsuwan: Project Leader). This NIH-funded study is conducted at Phramongkutklao hospital. The study has enrolled three groups of patients: 15 with HIV-associated dementia, 15 with no dementia and 30 HIV-negative controls. The patients will complete their 96-week follow up in January 2008. A substudy performed by Dr. Silvia Ratto-Kim showed that activated peripheral blood monocytes were maintained at high levels in HIV-negative controls and were non-discriminatory for HIV-associated dementia.

The baseline data has been published.

Valcour VG, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Ratto-Kim S, Apateerapong W, Shiramizu BT, Desouza MS, Chitpatima ST, Watt G, Chuenchitra T, Robertson KR, Paul RH, McArthur JC, Kim JH, Shikuma CM.Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection. Neurology. 2007 Feb 13;68(7):525-7.
PMID: 17296919 [PubMed - indexed for MEDLINE]

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